Miguel Angel Lozada, 30, 1614 Fairfield Pike, was westbound when his car ran off the left side of the road, came back across and was struck by an eastbound truck, Tennessee Highway Patrol Lt. Johnny Hunter said.
Investigators said the victim's small car was broken in half by the impact. Lozada was ejected during the crash, according to emergency workers.
Lozada, an employee of Genesco in Chapel Hill, was on his way to work, investigators said.
The truck's driver, James Rick Burnham, 29, and passenger, Jeremy Daugherty, 31, both of Chapel Hill, were less seriously injured.
Burnham suffered a broken leg and was taken to Bedford County Medical Center by ambulance, Hunter said. Daugherty was taken to Williamson Medical Center in Franklin by private vehicle for treatment of minor injuries.
Lozada was an employee of Genesco in Chapel Hill and the Bell Buckle Cafe. Burnham and Daugherty were en route to their jobs at the Nissan engine plant in Decherd, Hunter said.
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