After a slow start put the Tigerettes in a deep 19-5 hole after one quarter, head coach David Junkins' young squad played the Eaglettes tough before falling 64-39.
It was the first trip by Marshall County to Shelbyville since an 83-37 loss in 2001.
The two squads have met twice this decade in Lewisburg with Shelbyville winning both times, 42-37 in 2009 and 60-27 in 2002.
A steal and score by Tigerette sophomore Jameka Braden on the Eaglettes' first touch gave the visitors their only lead of the game at 2-0.
MCHS would stay in touch for much of the first quarter, and after a Mecia Reed free throw cut the Eaglettes' lead to 8-5 midway through the period, Shelbyville ran off 11 straight points to end the quarter with a fourteen-point lead.
Shelbyville's Kelsie Smith inflicted the most damage in the quarter, scoring 10 points and Smith ended up tied with teammate Brianna McDonald with a game high 24 points in the contest.
Braden scored the first five points of the second quarter to slice the Shelbyville's lead to 19-10 before the Eaglettes flew away again on a 9-0 burst to make it 28-10.
Braden, who scored a team high 19 points for the Tigerettes kept Shelbyville in sight with four straight markers to cut the lead in half.
By the end of the first half, the Tigerettes had hope as they only trailed by a dozen points, 33-21.
Early in the second half, a Destiny Moore bucket in the paint cut the Eaglettes' lead to ten points at 35-25.
The lead stayed at ten after a Michala Hopkins basket made it 37-27, but from there Shelbyville ran off and hid with an 8-2 run to end the quarter and led by sixteen points, entering the final eight minutes.
Marshall County would never get closer than fifteen points the remainder of the contest and lost by the 25-point margin.
Moore ended up with 8 points, Reed and Morgan Moyers netted 3 points apiece, Hopkins 2, and Marissa Lyttle had one free throw.
After a Tuesday night contest versus Columbia Central at Dottie Kelso Memorial Gymnasium in Lewisburg, the Tigerettes have three games at the Forrest Thanksgiving Tournament in Chapel Hill.
Marshall County takes on Cascade on Wednesday (9:00 a.m.), Loretto Friday (10:30 a.m.), and Creekwood Saturday (1:30 p.m.).