LMS scored a single basket in the first quarter by Katie Greer, but the Lady Tigers scored just six in the period to lead 6-2.
Makiya Morris opened up the second quarter with a steal and score for LMS to cut the lead to two points and that is where it would stay until late in the period when Zachuriya O'Neal came up with a steal and went the other way.
O'Neal's shot off the glass was off, but Morris was there for the put-back to tie the game at seven with fewer than two minutes remaining in the first half.
Whitthorne would end the half with a 4-1 spurt, sparked by back-to-back baskets by Tamijah Kinzer and Tasia Dial to lead 11-8 at the intermission.
LMS would still trail by five at 13-8 before a Morris bucket on one possession, followed by a Morris free throw on the next would slice the Whitthorne lead to two points at 13-11.
LMS would not score again in the third quarter as the Lady Tigers scored six unanswered points to end the period leading 19-11.
With four minutes and two seconds remaining in the third quarter, Dial dialed up a bucket to stretch the Whitthorne lead to 22-15 as things looked bleak for the Tigerettes.
LMS dug in, fighting back again and would cut the hometowners lead to two points on a Morris basket with 1:55 remaining in the contest.
The Tigerettes had a chance to tie on two separate occasions down the stretch, but could not convert and trailed 28-25 with 10.3 seconds left.
After a Lewisburg timeout, Morris drove to the hoop and her shot went high off the glass and was snatched by Taianda Hutton, who put it up and in and was hacked on the play.
LMS called timeout and Hutton went to the free throw to try to tie the game, but Whitthorne called a timeout to try to ice the youngster.
After the Whitthorne stoppage, Hutton calmly drilled the game tying free throw with one tick remaining in the game.
The contest went to overtime, tied at 28.
It was all Whitthorne from there as they outscored LMS 12-5 in extra time to win 40-33.
Morris led the Tigerettes with 20 points, Hutton finished with five, Lexie Allen had one trey, Alexia Ford and Greer scored two, and O'Neal had one point.
The loss evened the Tigerettes record on the season at 4-4.
LMS has three more road games at E.O. Coffman, Meridianville, and E.A. Cox before returning home on January 5 versus E.O. Coffman.