It was the fourth loss in a row for the Tigerettes (2-13), who take on McGavock on Thursday at East Literature.
Jameka Braden hit an open jumper on the Tigerettes' first touch and Smyrna's Miranda McCrary matched it to tie the game at two.
A Marissa Lyttle rebound and put-back made it 4-2, and after a Mecia Reed steal and score, all looked well for Marshall County.
From there it was downhill, as Smyrna scored 11 straight points to end the first quarter with a 13-6 lead.
One free throw by McCray to begin the second period made it an eight-point game before Morgan Moyers drilled a long trey to break the Lady Bulldogs' run.
The Tigerettes cut the lead to 16-12 moments later on a Lyttle three-point play in the paint, but they would not score again until the last possession of the half on a bucket by Kemesha McFall and trailed 26-14 at the intermission.
Smyrna would hold onto the double-digit lead for almost the entire third period until Moyers nailed another three-bomb and Braden scored on a rebound and put-back with six ticks remaining on the third quarter clock to make it a 36-29 ballgame, entering the final eight minutes of play.
Allie Bolton drilled a trey for Smyrna to open the fourth quarter, but the Tigerettes would not fold as Lyttle scored in the post and after a Lady Bulldog miscue, Moyers drilled her third trey of the ballgame to cut the Smyrna lead to five at 39-34.
Savannah McIntyre scored for Smyrna before Destiny Moore launched a three-bomb for the Tigerettes that found the bottom to slice the margin to just four points at 41-37 midway through the final period.
Bolton and Lyttle traded baskets to keep the margin at four points, but the Lady Bulldogs stretched the margin to eight points at 47-39 on consecutive baskets by Treasure Hunt and Bolton.
Lyttle scored again with under a minute to go, but that would be the last basket for the Tigerettes as they fell by the nine-point margin.
Lyttle led the Tigerettes in the scoring column with 11 points, Braden and Moyers had nine points apiece, Moore ended up with five, Megan Sanders had one three-pointer, and McFall and Reed netted two markers apiece.
Smyrna had a balanced scoring attack with no players in double figures as Bolton and Hunt scored nine, Brooklyn Blanchard and Kayla Hunt scored eight, Anisha Paul scored seven, McIntyre netted five, and McCray rounded out the scoring with four points.