Isley was on target in the contest as he did not walk any IMI batters and struck out three at the Jonathan D. Hollingsworth Memorial Field in Lewisburg.
Stuart Warner came on for Isley in the fifth inning and closed the door shut, allowing no hits the rest of the way.
Warner also did heavy damage at the plate, going 2-2 with one base on balls; a run scored and drove home three.
IMI starting pitcher Jordan Jent turned in a nice outing on the hill, giving up just three hits in his five innings of work on the hill.
Jent struck out seven and walked five Nichirin batters in the game for IMI (0-6), who turned in their best effort of the season.
IMI's lone base hit was a fourth inning single by Aaron Russ.
After Isley retired the side in order in the top of the first, Nichirin scored two runs in the bottom of the inning as David Looney singled with one out.
Looney stole second before Isley drew a walk.
Looney would score moments later on a wild pitch and Isley trotted home on Warner shot to left field before Jent got out of the inning on a pop-up to third and lineout to Brayden Gentry at shortstop.
Isley set down IMI in order in the second and third, and in the bottom of the third inning, Nichirin scored three times with the big blow coming on a Warner two-run triple.
Russ broke up Isley's no-hitter with a clean single to center field with one down in the fourth, but a 1-6-3 double play ended the inning.
Looney led off the home half of the fifth inning with a walk and proceeded to steal second and third base before trotting home with run number six on an RBI fielder's choice by Connor Mealer.
In the top of the sixth, Lucas Welch and Jake Blasingim bookended walks around a strikeout, but Warner induced a pop-up to first and ended the IMI threat with a strikeout.
In the home half of the sixth inning, Madison Peete drilled a leadoff double to left and came home with the game-ending, run-rule run on a base hit by Ta Ta Davis.