Alli Hobbs opened up the scoring in the ballgame with a rebound and put-back for LMS.
Mya Hamilton followed with the lone first quarter basket for the Alabama girls, tying the game at 2-2.
The Lady Eagles opened up the second quarter, scoring seven straight points, thanks to five from Claire Walker, including the go-ahead three-pointer that forced an LMS timeout with 2:19 remaining in the first half.
Hutton broke the LMS scoring drought moments later to make it 9-8, but Meridianville baskets from Keira Moore and Aazhenii Nye made it a 13-8 ballgame at the half.
O'Neal opened up the second half with a basket for Lewisburg before six straight points by the Lady Eagles put LMS in a 19-10 hole.
Two free throws by Leah Hollingsworth broke the Meridianville surge, but Walker scored on a rebound and put-back for the girls from Alabama at the end of the third period to open up a nine-point, 21-12 lead.
LMS would manage just three free throws in the final quarter, while Meridianville scored nine points to take control for good in the 15-point victory.
O'Neal scored six points to lead LMS in the losing effort, while Hutton had five and Hollingsworth and Hobbs finished with a deuce apiece.
Walker scored nine points to lead the Lady Eagles in the scoring column, while Nye ended up with six points.
Grace Guffey, Moore and Elizabeth Carter all netted four points apiece, Hamilton had the one basket to start the game and Ashlyn Smith rounded out the scoring with one marker.