LMS (4-0) jumped out to an early 4-0 lead behind D'Andre Brown, who scored the game's first basket and moments later, stole the ball and fed Tre Crutcher for a score.
Christian Cleveland finally got the Eagles from Alabama in the scoring column before Brown scored on one of two from the charity stripe and on another steal and score, making it 7-2 Lewisburg.
The Tigers' defense dug in and did not allow another Meridianville basket the remainder of the first quarter, while Brown ended up scoring his seventh point of the period near the end of the first six minutes of play.
Jay Howard scored to begin the second period, but the Eagles went on an offensive surge, scoring 15 out of the next 17 points in the game to take a 17-13 lead with 1:34 remaining in the first half.
A Crutcher steal and score, followed by a Caleb Fields rebound and put-back re-knotted the contest at 17.
Meridianville's Bradley Belt, who led all scorers in the game with 18 points, tallied his tenth point of quarter, drilling the second of his three-pointers at the buzzer to end the first half with the Eagles in the lead 20-17.
The Tigers would trail by four points twice in the third period with the last time at 28-24, before one free throw by Fields and a late basket on a rebound and put-back by Howard made it a one-point game at 28-27, entering the final six minutes.
Daniel Richardson scored for the Eagles to begin the final period, but a Keevon Maxwell three-bomb tied the game at 30 and ignited the Tigers' comeback.
A Brown basket after a Meridianville missed shot was followed by a Howard bucket off an Eagles' turnover to put LMS in front 34-30, forcing a timeout by the Alabama team with 3:49 remaining in the contest.
A few possessions later, Belt hit two free throws to make it 36-34.
Belt tried to keep his squad close with a basket to cut the Tigers' lead to three points, but it would not be enough as LMS held on for the five-point victory.
Brown led the Tigers in the scoring column with 15 points, Howard ended up with 12, Crutcher pitched in with 8 points and Fields and Maxwell finished with three points apiece.
Richardson had six points for Meridianville, Miles Battle and Ethan Stair ended up with four, and Cleveland and Tyler Harris both netted a deuce.